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A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles.
- Source :
- Human Reproduction; Sep2008, Vol. 23 Issue 9, p2010-2010, 1p
- Publication Year :
- 2008
-
Abstract
- <bold>Background: </bold>Our aim was to evaluate whether extending the interval between human chorionic gonadotrophin (hCG) priming and immature oocyte retrieval increases the oocyte maturation rate following in vitro maturation (IVM).<bold>Methods: </bold>This study was performed retrospectively. IVM was performed on 113 polycystic ovary syndrome patients (n = 120 cycles). Oocyte collection was performed either 35 h (Group 1; n = 76) or 38 h (Group 2; n = 44) after 10,000 IU of hCG priming. Following oocyte retrieval, oocyte maturity was assessed and the remaining immature oocytes were cultured in IVM medium up to Day 2.<bold>Results: </bold>The number of in vivo matured oocytes collected was significantly higher in Group 2 (13.6%, 114/840 versus 7.3%, 96/1312 in Group 1) (P < 0.01); the oocyte maturation rate after Day 1 was significantly higher (P < 0.01) in Group 2 (46.3 versus 36.0% in Group 1); and clinical pregnancy (40.9 versus 25%) and implantation rates (15.6 versus 9.6%) were better in Group 2 than those in Group 1.<bold>Conclusions: </bold>The results suggest that extending the period of hCG priming time from 35 to 38 h for immature oocyte retrieval promotes oocyte maturation in vivo and increases the IVM rate of immature oocytes. Therefore, oocyte retrieval after 38 h of hCG priming may improve subsequent pregnancy outcome in cycles programmed for IVM treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREGNANCY
CYCLES
OBSTETRICS
CONCEPTION
Subjects
Details
- Language :
- English
- ISSN :
- 02681161
- Volume :
- 23
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Human Reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 34032929
- Full Text :
- https://doi.org/10.1093/humrep/den210