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β2-Adrenoceptor Polymorphisms Predict Response to β2-Agonists in Children with Acute Asthma.

Authors :
Martin, Andrew C.
Zhang, Guicheng
Rueter, Kristina
Khoo, Siew-Kim
Bizzintino, Joelene
Hayden, Catherine M.
Geelhoed, Gary C.
Goldblatt, Jack
Laing, Ingrid A.
Le Souëf, Peter N.
Source :
Journal of Asthma; Jun2008, Vol. 45 Issue 5, p383-388, 6p, 4 Charts, 1 Graph
Publication Year :
2008

Abstract

The aim of this study was to determine the influence of single nucleotide polymorphisms in the β2-adrenoceptor gene, on the response to inhaled β2-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to β2-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for β2Arg16Gly and β2Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly β2-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1hourly: 2.6hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to β 2-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02770903
Volume :
45
Issue :
5
Database :
Complementary Index
Journal :
Journal of Asthma
Publication Type :
Academic Journal
Accession number :
34478137
Full Text :
https://doi.org/10.1080/02770900801971792