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Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma.
- Source :
- Histopathology; Oct2008, Vol. 53 Issue 4, p432-440, 9p, 1 Color Photograph, 1 Diagram, 2 Charts, 1 Graph
- Publication Year :
- 2008
-
Abstract
- Aims:  To elucidate the clinicopathological features and prognostic factors of primary intestinal diffuse large B-cell lymphoma (PI-DLBL). Methods and results:  Archival tissues from 30 tumours were used for tissue microarray construction, immunohistochemistry and interphase fluorescence in situ hybridization for chromosomal translocation. The M:F ratio was 1.7:1, with a median age of 60 years. The ileum and ileocaecum were most frequently involved (40% each). Fourteen (47%) were at stage I<subscript>E</subscript> disease, 15 (50%) at stage II<subscript>E</subscript>. Five (17%) tumours were perforated at presentation. The tumours expressed Bcl-6 (73%), MUM1 (70%), Bcl-2 (67%) and CD10 (23%). Nine (30%) were classified as germinal centre B-cell (GCB) phenotype and 21 non-GCB. Eight of 30 (27%), 7/30 (23%) and 2/29 (7%) cases were positive for rearrangements involving IGH, BCL6, and C-MYC loci, respectively, whereas all cases were negative for BCL2 and CCND1 translocation. Perforation was a poor prognostic indicator, with a hazard ratio of tumour-related death at 8.75 ( P = 0.001). The differentiation antigens, GCB versus non-GCB phenotype, or lymphoma-associated translocations were of no prognostic significance. Conclusions:  We found a higher rate of perforation and lower frequency of GCB phenotype in PI-DLBL in Taiwan compared with other geographical areas; perforation is a poor prognostic indicator. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03090167
- Volume :
- 53
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 34480518
- Full Text :
- https://doi.org/10.1111/j.1365-2559.2008.03140.x