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Truncated Tau with the Fyn-binding domain and without the microtubule-binding domain hinders the myelinating capacity of an oligodendrocyte cell line.
- Source :
- Journal of Neurochemistry; Oct2008, Vol. 107 Issue 2, p351-360, 10p, 1 Black and White Photograph, 7 Diagrams
- Publication Year :
- 2008
-
Abstract
- The mechanisms underlying developmental myelination have therapeutic potential following CNS injury and degeneration. We report that transplanted central glial (CG)-4 cells had a diminished myelinating capacity in myelin-deficient ( md) rats when cells express a mutated form of Tau (Tau [688]), which binds Fyn but not the microtubules. In the brain of the md rats, Tau [688]-transfected CG-4 cells displayed a decrease in cellular process outgrowth and myelination; in the spinal cord the extent of myelination rostral and caudal to the injection site was decreased. In contrast, control Tau [605]-transfected CG-4 cells formed long cellular processes and substantial areas of myelin both in the brain and spinal cord. In culture, Tau [688]-transfected CG-4 cells displayed a decrease in cellular process outgrowth, and Fyn localized largely in the cell body, not the processes. Thus, Tau in oligodendrocytes plays a key role in myelination, and a functional Tau-Fyn interaction might have therapeutic potential during demyelination and myelin repair following CNS injury and degeneration. [ABSTRACT FROM AUTHOR]
- Subjects :
- MYELINATION
BRAIN
SPINAL cord
CELL lines
CENTRAL nervous system
NEUROCHEMISTRY
Subjects
Details
- Language :
- English
- ISSN :
- 00223042
- Volume :
- 107
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Neurochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34571450
- Full Text :
- https://doi.org/10.1111/j.1471-4159.2008.05600.x