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Antisense Ki-67 cDNA Transfection Reverses the Tumorigenicity and Induces Apoptosis in Human Breast Cancer Cells.
- Source :
- Cancer Investigation; Dec2008, Vol. 26 Issue 8, p830-835, 6p, 2 Black and White Photographs, 3 Graphs
- Publication Year :
- 2008
-
Abstract
- Effects of antisense Ki-67 cDNA transfection on breast cancer cells were investigated in this study. Transfection of antisense Ki-67 cDNA resulted in a 70%-80% reduction in proliferation of MDA-MB-435s, cells which highly expressed Ki-67 mRNA and protein. Transwell assay showed that mobility and invasion capability was dramatically inhibited by 50%-60%, and cell cycle analysis displayed a higher proportion in G2/M and G0/G1 phases accompanied by remarkably increased ratio of apoptotic cells. Our results suggested that antisense Ki-67 cDNA vector treatment might be an important potential option in the anticancer therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTISENSE DNA
DNA
GENE transfection
CANCER cells
BREAST cancer
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 26
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 34727682
- Full Text :
- https://doi.org/10.1080/07357900801941878