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Blood glucose and insulin concentrations are reduced in humans administered sucrose with inosine or adenosine.
- Source :
- Journal of Nutrition; Aug2000, Vol. 130 Issue 8, p1946-1949, 4p, 2 Diagrams, 2 Graphs
- Publication Year :
- 2000
-
Abstract
- Recently we found that some nucleosides such as inosine or adenosine inhibited alpha-glucosidase from rat intestine. The aim of this study was to determine whether these nucleosides are sucrase inhibitors in humans as well as rats. Blood glucose and insulin responses were examined in 23 healthy volunteers (18 males and 5 females) administered sucrose with inosine and 8 (males) administered sucrose with adenosine. The initial increase in plasma glucose and serum insulin concentrations at 30 min after loading sucrose (50 g) alone were significantly reduced by co-administration of inosine (2.5 and 1.0 g) or adenosine (2.5 g). The total increases in the areas under the plasma glucose and serum insulin concentration curves for 3 h after administration of the same amount of sucrose with inosine were also significantly less than those when the volunteers were administered sucrose alone. These results in humans agree with the findings obtained in our previous studies in rats. These nucleosides may be used as one of the components of artificial sweeteners when mixed with sucrose and may be useful as food additives to suppress increases in blood glucose and insulin. [ABSTRACT FROM AUTHOR]
- Subjects :
- NUCLEOSIDES
RATS
BLOOD sugar analysis
INSULIN
INOSINE
DIGESTIVE organs
ADENOSINES
BLOOD sugar
COMPARATIVE studies
CLINICAL drug trials
ENZYME inhibitors
GLYCOSIDASES
GLYCOSIDES
RESEARCH methodology
MEDICAL cooperation
RESEARCH
SUCROSE
SWEETENERS
EVALUATION research
CHEMICAL inhibitors
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00223166
- Volume :
- 130
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 3533460
- Full Text :
- https://doi.org/10.1093/jn/130.8.1946