Effect of PVP K30 and/or l-Arginine on Stability Constant of Etoricoxib-HPβCD Inclusion Complex: Preparation and Characterization of Etoricoxib-HPβCD Binary System.

The effect of polyvinyl pyrrolidone (PVP) K30 and/or l-arginine on etoricoxib-HPβCD complex was investigated. The phase solubility profiles were classified as AL-type, both in absence or presence of auxiliary substances used. The apparent stability constant (Kc) of binary complex obtained at room temperature, 371.80 ± 2.61 M-1, was decreased with the addition of PVP and arginine indicating no benefit of addition of auxiliary substances to promote higher complexation efficiency. Therefore, solid etoricoxib-HPβCD binary systems were prepared and characterized by proton nuclear magnetic resonance spectroscopy (1HNMR), X-ray powder diffractometry, Fourier transformation-infrared spectroscopy, and dissolution studies. Among all binary systems, a lyophilized product showed superior performance in enhancing dissolution of etoricoxib. [ABSTRACT FROM AUTHOR]