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Modeling the In Vivo Case with In Vitro Nanotoxicity Data.
- Source :
- International Journal of Toxicology (Taylor & Francis); Oct2008, Vol. 27 Issue 5, p359-367, 9p, 1 Diagram, 1 Chart, 6 Graphs
- Publication Year :
- 2008
-
Abstract
- As more in vitro nanotoxicity data appear in the literature, these findings must be translated to in vivo effects to define nanoparticle exposure risk. Physiologically based pharmacokinetic (PBPK) modeling has played a significant role in guiding and validating in vivo studies for molecular chemical exposure and can develop as a significant tool in guiding similar nanotoxicity studies. This study models the population dynamics of a single cell type within a specific tissue. It is the first attempt to model the in vitro effects of a nanoparticle exposure, in this case aluminum (80 nm) and its impact on a population of rat alveolar macrophages (Wagner et al. 2007, J. Phys. Chem. B 111:7353-7359). The model demonstrates how in vitro data can be used within a simulation setting of in vivo cell dynamics and suggests that PBPK models should be developed quickly to interpret nanotoxicity data, guide in vivo study design, and accelerate nanoparticle risk assessment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10915818
- Volume :
- 27
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- International Journal of Toxicology (Taylor & Francis)
- Publication Type :
- Academic Journal
- Accession number :
- 35484596
- Full Text :
- https://doi.org/10.1080/10915810802503487