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Estrogen Replacement Suppresses Pressor Response and Oxidative Stress Induced by Cage-switch Stress in Ovariectomized Rats.
- Source :
- Annals of the New York Academy of Sciences; Dec2008, Vol. 1148, p213-218, 6p, 2 Graphs
- Publication Year :
- 2008
-
Abstract
- We examined the suppressive effects of estradiol on psychological stress–induced cardiovascular responses and oxidative stress in ovariectomized rats, both placebo-treated (OVX+Pla) and estrogen-treated (OVX+E2). The elevations in blood pressure and heart rate induced by cage-switch stress were attenuated in the OVX+E2 as compared with the OVX+Pla group. N<superscript>G</superscript>-nitro-L-arginine methyl ester, administered via drinking water, reduced the difference in these responses. Furthermore, this stress increased plasma nitrotyrosine and decreased plasma nitric oxide (NO) metabolites only in the OVX+Pla group. We demonstrated that estrogen replacement suppresses cardiovascular responses to psychological stress, at least in part by improving NO bioavailability in ovariectomized rats. [ABSTRACT FROM AUTHOR]
- Subjects :
- PSYCHOLOGICAL stress
ESTROGEN
OXIDATIVE stress
ESTRADIOL
NITRIC oxide
LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1148
- Database :
- Complementary Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35641466
- Full Text :
- https://doi.org/10.1196/annals.1410.045