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The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production.
- Source :
- BMC Immunology; 2008, Vol. 9, Special section p1-14, 14p, 4 Charts, 8 Graphs
- Publication Year :
- 2008
-
Abstract
- Background: We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma; and TNF-α expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Here, we have demonstrated that the observed effects using ATRA and 9-cis RA are shared with the clinically useful RAR ligand, 13-cis retinoic acid (13-cis RA), and the retinoic acid receptor-α (RAR-α)-selective agonist, AM580 but not with the RAR-β/γ ligand, 4-hydroxyphenylretinamide (4-HPR). Results: The increase in type 2 cytokine production by these retinoids correlated with the expression of the T cell activation markers, CD69 and CD38. The RAR-α-selective agonist, AM580 recapitulated all of the T cell activation and type 2 cytokine-inducing effects of ATRA and 9-cis-RA, while the RAR-α-selective antagonist, RO 41-5253, inhibited these effects. Conclusion: These results strongly support a role for RAR-α engagement in the regulation of genes and proteins involved with human T cell activation and type 2 cytokine production. [ABSTRACT FROM AUTHOR]
- Subjects :
- TRETINOIN
DERMATOLOGIC agents
T cells
CELLS
LIGANDS (Biochemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 14712172
- Volume :
- 9
- Database :
- Complementary Index
- Journal :
- BMC Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 35701914
- Full Text :
- https://doi.org/10.1186/1471-2172-9-16