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The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
- Source :
- BMC Immunology; 2008, Vol. 9, Special section p1-12, 12p, 1 Chart, 4 Graphs
- Publication Year :
- 2008
-
Abstract
- Background: CD4<subscript>+</subscript>CD25<superscript>high</superscript> regulatory T (T<subscript>Reg</subscript>) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. In HTLV-1 infection, a selective decrease in the function of T<subscript>Reg</subscript> cell mediated HTLV-1-tax inhibition of FOXP3 expression has been described. The purpose of this study was to assess the frequency and phenotype of T<subscript>Reg</subscript> cells in HTLV-1 asymptomatic carriers and in HTLV-1-associated neurological disease (HAM/TSP) patients, and to correlate with measures of T cell activation. Results: We were able to confirm that HTLV-I drives activation, spontaneous IFNγ production, and proliferation of CD4+ T cells. We also observed a significantly lower proportion of CTLA-4<subscript>+</subscript> T<subscript>Reg</subscript> cells (CD4<subscript>+</subscript>CD25<superscript>high</superscript> T cells) in subjects with HAM/TSP patients compared to healthy controls. Ki-67 expression was negatively correlated to the frequency of CTLA-4<subscript>+</subscript> T<subscript>Reg</subscript> cells in HAM/TSP only, although Ki-67 expression was inversely correlated with the percentage of CD127<superscript>low</superscript> T<subscript>Reg</subscript> cells in healthy control subjects. Finally, the proportion of CD127<superscript>low</superscript> T<subscript>Reg</subscript> cells correlated inversely with HTLV-1 proviral load. Conclusion: Taken together, the results suggest that T<subscript>Reg</subscript> cells may be subverted in HAM/TSP patients, which could explain the marked cellular activation, spontaneous cytokine production, and proliferation of CD4<superscript>+</superscript> T cells, in particular those expressing the CD25<superscript>high</superscript>CD127<superscript>low</superscript> phenotype. T<subscript>Reg</subscript> cells represent a potential target for therapeutic intervention for patients with HTLV-1-related neurological diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELLS
ORGANISMS
ANTIGENS
T cells
PHENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 14712172
- Volume :
- 9
- Database :
- Complementary Index
- Journal :
- BMC Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 35701942
- Full Text :
- https://doi.org/10.1186/1471-2172-9-41