T-cell development: CD40–CD40L crosstalk in TH17-cell differentiation.

The article provides information on an immunological research involving the differentiation of T helper 17 cells. It is stated that a present study has indicated that CD40-CD40 ligand crosstalk is needed for the cell differentiation of Th 17 cells in vitro and in vivo. Data in the study has showed that strong antigenic and pathogenic stimuli worked together to drive Th 17-cell differentiation.