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Non-coding RNAs revealed during identification of genes involved in chicken immune responses.
- Source :
- Immunogenetics; Jan2009, Vol. 61 Issue 1, p55-70, 16p, 1 Black and White Photograph, 3 Diagrams, 3 Charts, 3 Graphs
- Publication Year :
- 2009
-
Abstract
- Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response. [ABSTRACT FROM AUTHOR]
- Subjects :
- MESSENGER RNA
VIRUS diseases
DNA microarrays
IMMUNE response
CHICKENS
Subjects
Details
- Language :
- English
- ISSN :
- 00937711
- Volume :
- 61
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 36336058
- Full Text :
- https://doi.org/10.1007/s00251-008-0337-8