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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.
- Source :
- Nature; 9/28/2000, Vol. 407 Issue 6803, p538, 4p, 17 Black and White Photographs, 8 Graphs
- Publication Year :
- 2000
-
Abstract
- Shows that the oestrogen receptor (ER) isoform, ER alpha, binds in a ligand-dependent manner to the p85 alpha regulatory subunit of phosphatidylinositol-3-oxygen-hydrogen kinase (PI(3)K). Effect of stimulation with oestrogen on ER alpha-associated PI(3)K activity; Role of the oestrogen receptor in mediating the cardiovascular protective effects of oestrogen; Definition of a physiologically important non-nuclear oestrogen-signalling pathway involving direct interaction of ER alpha with PI(3)K.
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 407
- Issue :
- 6803
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 3644741
- Full Text :
- https://doi.org/10.1038/35035131