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In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis.
- Source :
- International Journal of Cardiovascular Imaging; Mar2009, Vol. 25 Issue 3, p251-257, 7p
- Publication Year :
- 2009
-
Abstract
- Abstract  We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 ± 0.02 to 0.68 ± 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 ± 0.02 to 0.53 ± 0.02, P  [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15695794
- Volume :
- 25
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Journal of Cardiovascular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 36526196