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Natural CD4+ T-cell responses against Trypanosoma cruzi KMP-11 protein in chronic chagasic patients.
- Source :
- Immunology & Cell Biology; Feb2009, Vol. 87 Issue 2, p149-153, 5p, 2 Charts, 3 Graphs
- Publication Year :
- 2009
-
Abstract
- Trypanosoma cruzi kinetoplastid membrane protein-11 (KMP-11) is able to induce protective immunity in mice. In humans, T-cell immunity during Chagas disease has been documented using parasite antigens allowing the identification of specific CD8<superscript>+</superscript> T cells. However, little is known about the CD4<superscript>+</superscript> T-cell response during the evolution of the disease. In this paper, the induction of a natural CD4<superscript>+</superscript> T-cell response against the KMP-11 protein in T. cruzi infected humans was studied to assess whether this parasite-derived protein could be processed, presented and detected as a major histocompatibility complex class II restricted epitope. The results show that helper T cells from 5 out of 13 chagasic patients specifically produced interferon-γ after exposure to the KMP-11 antigen, whereas healthy donors and non-chagasic cardiopathic patients did not respond. This is the first description of T. cruzi KMP-11 protein recognition by CD4<superscript>+</superscript> T cells in chronic chagasic patients.Immunology and Cell Biology (2009) 87, 149–153; doi:10.1038/icb.2008.76; published online 28 October 2008 [ABSTRACT FROM AUTHOR]
- Subjects :
- TRYPANOSOMA
T cells
KINETOPLASTIDA
ANTIGENS
INTERFERONS
Subjects
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 87
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 36555353
- Full Text :
- https://doi.org/10.1038/icb.2008.76