Antigen presentation: Parasite hijacking.

The article reports on the study which focuses on Toxoplasma gondii tachyzoites that have infected host cells residing in the parasitophorous vacuole (PV). Researchers have generated a system which will permit them to trace antigen-specific T-cell responses to T. gondii-derived antigens espousing phagocytosis of infected cells or dead parasites. It reveals that T. gondii-derived antigens are cross-presented by major histocompatibility complex (MHC) class I molecules to CD8⁺ cells.