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The role of TNF superfamily members in T-cell function and diseases.
- Source :
- Nature Reviews Immunology; Apr2009, Vol. 9 Issue 4, p271-285, 15p, 4 Diagrams, 3 Charts
- Publication Year :
- 2009
-
Abstract
- Interactions that occur between several tumour necrosis factor (TNF)-TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand-receptor interactions - OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 - and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating diseases in which T cells have an important role, including inflammatory conditions, autoimmunity and cancer. Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 9
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 37138443
- Full Text :
- https://doi.org/10.1038/nri2526