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HDP--A Novel Heme Detoxification Protein from the Malaria Parasite.
- Source :
- PLoS Pathogens; Apr2008, Vol. 4 Issue 4, p1-15, 15p, 2 Black and White Photographs, 3 Diagrams, 2 Graphs
- Publication Year :
- 2008
-
Abstract
- When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein (HDP) that is extremely potent in converting heme into Hz. HDP is functionally conserved across Plasmodium genus and its gene locus could not be disrupted. Once expressed, the parasite utilizes a circuitous ''Outbound-Inbound'' trafficking route by initially secreting HDP into the cytosol of infected RBC. A subsequent endocytosis of host cytosol (and hemoglobin) delivers HDP to the food vacuole (FV), the site of Hz formation. As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target. [ABSTRACT FROM AUTHOR]
- Subjects :
- PLASMODIUM
ERYTHROCYTES
CYTOSOL
HEMOGLOBIN polymorphisms
HEME
PROTOZOAN diseases
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 4
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 37295080
- Full Text :
- https://doi.org/10.1371/journal.ppat.1000053