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Investigations on the Effect of Flavonoids from Banana, Musa Paradisiaca L. on Lipid Metabolism in Rats.
- Source :
- Journal of Dietary Supplements; 2009, Vol. 6 Issue 2, p111-123, 13p
- Publication Year :
- 2009
-
Abstract
- Oral administration of flavonoids extracted from unripe fruits of Musa paradisiaca showed significant hypolipidemic activities in male rats (Sprague Dawley strain) at a dose of 1 mg/100 g body weight (BW)/day. Concentrations of cholesterol, phospholipids, free fatty acids, and triglycerides showed significant decrease in the serum, liver, kidney, and brain of experimental animals. HMG CoA reductase activity was found to be enhanced, while activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Activities of lipoprotein lipase and plasma LCAT showed significant enhancement. A significant increase in the concentrations of hepatic and fecal bile acids and fecal neutral sterols was also observed indicating a higher rate of degradation of cholesterol. The present study indicates that although there is an increase in the rate of synthesis of cholesterol in the liver, the process of degradation exceeds the rate of synthesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLAVONOIDS
CHOLESTEROL
STEROLS
SERUM
TRIGLYCERIDES
LIPOPROTEINS
RESEARCH
Subjects
Details
- Language :
- English
- ISSN :
- 19390211
- Volume :
- 6
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Dietary Supplements
- Publication Type :
- Academic Journal
- Accession number :
- 38798100
- Full Text :
- https://doi.org/10.1080/19390210902861825