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Decreased Expression of p12 Is Associated with More Advanced Tumor Invasion in Human Gastric Cancer Tissues.
- Source :
- European Surgical Research; 2009, Vol. 42 Issue 4, p223-229, 7p, 1 Color Photograph, 4 Charts, 1 Graph
- Publication Year :
- 2009
-
Abstract
- Background/Aims: p12<superscript>DOC-1</superscript> is a well-known growth suppressor; however, its role in gastric carcinogenesis is still unclear. We investigated the expression of p12<superscript>DOC-1</superscript> in gastric cancer tissues and its possible correlation with p53 expression, and determined its clinical significance. Methods: Immunohistochemical staining using the tissue array method was performed on 180 human gastric carcinomas. The clinicopathological features and prognostic significance were analyzed. Results: Of the 180 tissue samples, p53 expression was positive in 85 (47.2%) and p12<superscript>DOC-1</superscript> expression was negative in 140 (77.8%). The negative expression of p12<superscript>DOC-1</superscript> was significantly associated with a more advanced depth of tumor invasion and stage (p < 0.05). No apparent correlation was found between p12<superscript>DOC-1</superscript> and p53 expressions. The 5-year survival rate of the p12<superscript>DOC-1</superscript>-positive cases (53.7%) was higher than that of the p12<superscript>DOC-1</superscript>-negative cases (39.3%); however, neither p12<superscript>DOC-1</superscript> nor p53 expression status had any statistically significant prognostic value. Multivariate analysis revealed that lymph node metastasis, distant metastasis, lymphatic invasion and perineural invasion were independent prognostic factors. Conclusions: This is the first report that suggests that p12<superscript>DOC-1</superscript> may be involved in the development and progression of gastric cancer. Further studies are required to clarify its exact role in the mechanism of gastric carcinogenesis. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0014312X
- Volume :
- 42
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- European Surgical Research
- Publication Type :
- Academic Journal
- Accession number :
- 39892400
- Full Text :
- https://doi.org/10.1159/000208521