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Bacteremia among Kidney Transplant Recipients: a Case-control Study of Risk Factors and Short-term Outcomes.
- Source :
- Scandinavian Journal of Infectious Diseases; 2000, Vol. 32 Issue 1, p69-73, 5p, 3 Charts
- Publication Year :
- 2000
-
Abstract
- Kidney transplant recipients are highly susceptible to life-threatening infections, including bacteremia. To determine the risk factors for bacteremia within the first month after renal transplantation we performed a non-concurrent transplant population-based case-control study involving all 1,000 consecutively operated adult patients at Helsinki University Central Hospital in 1987-93. All patients with at least 1 positive blood culture within 31 d of transplantation were defined as cases. Control patients were drawn systematically from the transplant population with no positive blood cultures within the first 31 d post-transplant. The study included 35 cases and 123 controls. The overall rate of bacteremia in the population was 3.5%. The case patients were more likely to have been on haemodialysis prior to transplantation (71% vs. 43%, p <0.05) and to have experienced acute rejection (46% vs. 20%, p<0.05) than the controls. Local infections (46% vs. 12%, p<0.05) were also more common among case patients. In the crude analysis an additive interaction of acute rejection and haemodialysis was found, with a 10% rate of bacteremia occurring if both conditions were present. The mortality rate within 2 months of follow-up was higher among case patients than among controls (14% vs. 1%, p<0.05) and they also returned more often to dialysis (23% vs. 4%, p<0.05). Bacteremia during the immediate postoperative period might still have severe outcomes measured as allograft and patient survival at 2 months post-transplant. Further evaluation will confirm whether a lower rate of bacteremia among kidney transplantation patients can be achieved if peritoneal dialysis is preferred to haemodialysis whenever possible. [ABSTRACT FROM AUTHOR]
- Subjects :
- KIDNEY transplantation
BACTEREMIA
COMPLICATIONS from organ transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 00365548
- Volume :
- 32
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 4140259
- Full Text :
- https://doi.org/10.1080/00365540050164254