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MMP-14 can serve as a prognostic marker in patients with supraglottic cancer.
- Source :
- European Archives of Oto-Rhino-Laryngology; Sep2009, Vol. 266 Issue 9, p1427-1434, 8p, 1 Color Photograph, 1 Black and White Photograph, 7 Charts, 1 Graph
- Publication Year :
- 2009
-
Abstract
- The purpose of this study was to examine the expression of MMP-14, 15 and 16 (MT1, MT2 and MT3-MMP) in supraglottic carcinoma and to explore their clinical significance. Expression of MMP-14, 15 and 16 was examined using RT-PCR and immunohistochemistry methods in samples from 85 cases of supraglottic carcinoma. Results showed that both mRNA and protein expression of MMP-14, 15 and 16 were increased in supraglottic carcinoma tissues compared to expression in control adjacent non-neoplastic tissues ( P < 0.05). Expression of MMP-14, but not MMP-15 and MMP-16, was significantly increased in the T3 and neck nodal metastasis groups compared with the T1–2 group and the group without nodal metastasis at both mRNA and protein levels ( P < 0.05). Expression of MMP-14 mRNA and protein was also higher in tumors of patients with stage III–IV disease compared to patients with clinical stage I–II tumors ( P < 0.05). Kaplan–Meier survival curves showed that the groups with high MMP-14 protein expression had a poorer prognosis than patients in the groups with weak or negative expression of MMP-14 protein ( P < 0.05). In conclusion, MMP-14 may play an important role in the progression of supraglottic carcinoma and may be a novel prognostic factor for patients with supraglottic carcinoma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09374477
- Volume :
- 266
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- European Archives of Oto-Rhino-Laryngology
- Publication Type :
- Academic Journal
- Accession number :
- 43467990
- Full Text :
- https://doi.org/10.1007/s00405-009-0943-6