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Bax activation by Bim?
- Source :
- Cell Death & Differentiation; Sep2009, Vol. 16 Issue 9, p1187-1191, 5p, 4 Diagrams
- Publication Year :
- 2009
-
Abstract
- The mechanism by which the cell death mediator Bax becomes activated to cause mitochondrial damage, a key step for the intrinsic pathway to apoptosis, remain highly contentious. Although some data support a role for certain BH3-only proteins, such as Bim or tBid, to directly activate Bax, others have led to the conclusion that BH3-only proteins act indirectly by antagonizing the prosurvival Bcl-2 proteins, thereby allowing Bax activation to proceed. A recent paper in Nature by Gavathiotis et al. provides the first biophysical evidence for a direct interaction between a BH3 domain, that of Bim, with Bax. Here, we review these intriguing observations and discuss their implications for our understanding of how the BH3-only proteins initiate apoptosis.Cell Death and Differentiation (2009) 16, 1187–1191; doi:10.1038/cdd.2009.83; published online 26 June 2009 [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL death
MITOCHONDRIA
APOPTOSIS
PROTEINS
BIOMOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 13509047
- Volume :
- 16
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Cell Death & Differentiation
- Publication Type :
- Academic Journal
- Accession number :
- 43713147
- Full Text :
- https://doi.org/10.1038/cdd.2009.83