A Polymorphism Within IL21R Confers Risk for Systemic Lupus Erythematosus.

Authors :: Webb, Ryan
Merrill, Joan T.
Kelly, Jennifer A.
Sestak, Andrea
Kaufman, Kenneth M.
Langefeld, Carl D.
Ziegler, Julie
Kimberly, Robert P.
Edberg, Jeffrey C.
Ramsey-Goldman, Rosalind
Petri, Michelle
Reveille, John D.
Alarcón, Graciela S.
Vilá, Luis M.
Alarcon-Riquelme, Marta E.
James, Judith A.
Gilkeson, Gary S.
Jacob, Chaim O.
Moser, Kathy L.
Gaffney, Patrick M.
Source :: Arthritis & Rheumatism; Aug2009, Vol. 60 Issue 8, p2402-2407, 6p, 2 Graphs, 2 Maps
Publication Year :: 2009
Abstract: The article presents information on a study concerning the genetic relationship between single-nucleotide polymorphisms (SNPs) within systemic lupus erythematosus (SLE) and interleukin-21 receptor (IL21R). It features SLE as a chronic systematic autoimmune disease related to multiple organs. Results of the study suggest that IL21R is a novel susceptibility gene for SLE. It also indicates the importance of IL21R in understanding the origin and development of SLE.