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High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice.
- Source :
- Cardiovascular Research; Oct2008, Vol. 80 Issue 1, p40-46, 7p, 1 Color Photograph, 1 Diagram, 2 Charts, 4 Graphs
- Publication Year :
- 2008
-
Abstract
- Aims: High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein and is released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. To test the hypothesis that HMGB1 enhances angiogenesis and restores cardiac function after myocardial infarction (MI), we generated transgenic mice with cardiac-specific overexpression of HMGB1 (HMGB1-Tg) using α-myosin heavy chain promoter. [ABSTRACT FROM PUBLISHER]
- Subjects :
- DNA
DNA-binding proteins
CELLS
INFLAMMATION
NEOVASCULARIZATION
MYOCARDIAL infarction
Subjects
Details
- Language :
- English
- ISSN :
- 00086363
- Volume :
- 80
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Cardiovascular Research
- Publication Type :
- Academic Journal
- Accession number :
- 44394553
- Full Text :
- https://doi.org/10.1093/cvr/cvn163