Back to Search
Start Over
The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.
- Source :
- British Journal of Rheumatology; Apr1998, Vol. 37 Issue 4, p454-458, 5p
- Publication Year :
- 1998
-
Abstract
- The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 02637103
- Volume :
- 37
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- British Journal of Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 44590437
- Full Text :
- https://doi.org/10.1093/rheumatology/37.4.454