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Contribution of the MexAB-OprM multidrug efflux system to the beta-lactam resistance of penicillin-binding protein and beta-lactamase-derepressed mutants of Pseudomonas aeruginosa.
- Source :
- Journal of Antimicrobial Chemotherapy (JAC); Oct1999, Vol. 44 Issue 4, p537-540, 4p
- Publication Year :
- 1999
-
Abstract
- Deletion of the mexAB-oprM multidrug efflux operon substantially compromised the β-lactam resistance of β-lactamase-derepressed mutants of Pseudomonas aeruginosa, although it had only a modest impact on resistance of a penicillin-binding protein mutant. This highlights the multifactorial nature of β-lactam resistance in this organism. Moreover, the contribution of efflux to the net resistance seen in some β-lactam-resistant mutants suggests that inhibition of MexAB-OprM-mediated drug efflux might be an effective approach to overcoming β-lactam resistance attributed to efflux as well as to other mechanisms of β-lactam resistance. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 03057453
- Volume :
- 44
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Academic Journal
- Accession number :
- 44609426
- Full Text :
- https://doi.org/10.1093/jac/44.4.537