Production of platelet-activating factor in patients with sepsis-associated acute renal failure.

Background. Studies in experimental animals have suggested that platelet-activating factor (PAF) is a mediator of sepsis-associated acute renal failure (ARF). In the present study we have evaluated whether an increased concentration of PAF within circulation of urine of septic patients correlated with the worsening of renal function. [ABSTRACT FROM PUBLISHER]