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Structural insight into mammalian sialyltransferases.
- Source :
- Nature Structural & Molecular Biology; Nov2009, Vol. 16 Issue 11, p1186-1188, 3p, 2 Diagrams
- Publication Year :
- 2009
-
Abstract
- Sialic acid is the most abundant terminal monosaccharide on mammalian cell surface glycoconjugates. The crystal structures of a mammalian sialyltransferase, that of porcine ST3Gal-I, in the apo form and bound to analogues of the donor and acceptor substrate are now described, providing insights into the catalytic mechanism and for inhibitor design. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15459993
- Volume :
- 16
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Nature Structural & Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- 44966283
- Full Text :
- https://doi.org/10.1038/nsmb.1685