Indirect Determination of Ranitidine Hydrochloride Using a Chloride Ion Selective Electrode.

A simple, rapid, and reliable potentiometric method is described for determination of ranitidine hydrochloride in pharmaceutical formulations. Experiments were performed to determine the suitability of using a chloride-ion selective electrode for the indirect estimation of ranitidine hydrochloride. The precision and accuracy of the potentiometric method were determined. We found that they not differ significantly. The advantage of the proposed method is the fact that it can be applied without filtration of the drug sample before analysis. [ABSTRACT FROM AUTHOR]