Expression of TGF-β receptors type I and II in human glomerulonephritis.

Background.Transforming growth factor-β (TGF-β) is a multipotent cytokine involved in the turnover of the extracellular matrix. Signal transduction of TGF-β is regulated via at least five different surface receptors; most of the effects, however, are mediated through the interaction of receptors type I and II (RI and RII). We investigated the glomerular expression of TGF-β and its receptors RI and RII in human glomerulonephritis. [ABSTRACT FROM PUBLISHER]