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Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions.
- Source :
- Human Reproduction; Oct2001, Vol. 16 Issue 10, p2219-2226, 8p
- Publication Year :
- 2001
-
Abstract
- <bold>Background: </bold>This study compared Th1-Th2 cytokine profiles in a subgroup of recurrent aborters who had an abortion with those in a subgroup of recurrent aborters who had a successful pregnancy.<bold>Methods: </bold>Fifty-four women with a history of at least three normal pregnancies, 24 women with a history of recurrent spontaneous abortion (RSA) followed by abortion (RSA-->A) and 39 women with a history of RSA followed by normal pregnancy (RSA-->N) were studied. Blood samples and placentas were obtained at the time of delivery or abortion; peripheral blood mononuclear cells were stimulated separately with phytohaemagglutinin and with autologous placental cells, and the secreted cytokines estimated.<bold>Results: </bold>Peripheral blood mononuclear cells from the RSA-->N subgroup secreted higher concentrations of Th1-type cytokines as compared with normal pregnant women, indicating a higher Th1 bias in these women. However, women in the RSA-->N subgroup had significantly higher concentrations of Th2 cytokines as compared with women in the RSA-->A subgroup. A comparison of Th1:Th2 cytokine ratios indicated a higher Th2 bias in RSA-->N women as compared with RSA-->A women.<bold>Conclusions: </bold>We conclude that abortion-prone women who proceed to have successful pregnancy are more Th2-biased than abortion-prone women who abort, and that recurrent aborters who undergo spontaneous abortion have a stronger Th1 bias than aborters who have normal pregnancy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02681161
- Volume :
- 16
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Human Reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 45343823
- Full Text :
- https://doi.org/10.1093/humrep/16.10.2219