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Late-onset immune-mediated adverse effects after poly-L-lactic acid injection in non-HIV patients: clinical findings and long-term follow-up.
- Source :
- Dermatology (10188665); Nov2009, Vol. 219 Issue 4, p303-308, 6p, 3 Charts
- Publication Year :
- 2009
-
Abstract
- <bold>Background: </bold>It has been thought that poly-L-lactic acid (PLLA) injections do not have inflammatory side effects. Recent evidence shows that local/regional/systemic delayed adverse effects may appear with its use.<bold>Objective: </bold>To evaluate the clinical complaints, treatment response and long-term follow-up of non-HIV patients with delayed immune-mediated adverse effects related to PLLA injections.<bold>Methods: </bold>Prospective, case series study of 10 patients with delayed adverse effects related to PLLA injections. The inclusion criterion was defined as the onset at least 6 months after PLLA use, with 1 or more of the following clinical signs: oedema, skin induration, swelling/tender nodules with or without discharge of pus or filler material. Several systemic manifestations were also included. Patients with immediate side effects were excluded. Patients underwent clinical management and long-term follow-up.<bold>Results: </bold>The average latency period to the onset of symptoms was 19.2 months (range: 6-60). Tender, inflammatory nodules and facial oedema were commonly seen. One case presented a systemic granulomatous disorder as a complication. After 50.2 months of average follow-up (range: 38-78), 5 patients are in remission, 4 have recurrent bouts and the last case has been lost to follow-up.<bold>Conclusion: </bold>Although infrequently, local and/or regional and/or systemic delayed and recurrent granulomatous reactions may complicate PLLA gel injections. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10188665
- Volume :
- 219
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Dermatology (10188665)
- Publication Type :
- Academic Journal
- Accession number :
- 45551096
- Full Text :
- https://doi.org/10.1159/000243804