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PET imaging of medullary thyroid carcinoma in MEN2A transgenic mice using 6-[18F]F- L-DOPA.
- Source :
- European Journal of Nuclear Medicine & Molecular Imaging; Jan2010, Vol. 37 Issue 1, p58-66, 9p, 1 Color Photograph, 1 Chart, 3 Graphs
- Publication Year :
- 2010
-
Abstract
- 6-[<superscript>18</superscript>F]Fluoro-3,4-dihydroxy- L-phenylalanine (6-[<superscript>18</superscript>F]F- L-DOPA) is increasingly used for PET imaging of neuroendocrine tumours. In this study, we investigated the use of 6-[<superscript>18</superscript>F]F- L-DOPA to detect and to monitor the progression of medullary thyroid carcinoma (MTC) in a genetically engineered mouse model of multiple endocrine neoplasia type 2A (MEN2A). Dynamic [<superscript>18</superscript>F]FDG and 6-[<superscript>18</superscript>F]F- L-DOPA small animal PET scans were acquired during 60 or 90 min in 8- to 20-month-old MEN2A transgenic mice. The kinetics of 6-[<superscript>18</superscript>F]F- L-DOPA, standardized uptake values (SUV) at 60 min and tumour volumes were recorded. The detection of MTCs using PET was confirmed by autopsy and histological analysis. 6-[<superscript>18</superscript>F]F- L-DOPA performs better than [<superscript>18</superscript>F]FDG for MTC detection in this transgenic mouse model. Uptake kinetics of 6-[<superscript>18</superscript>F]F- L-DOPA in MTCs are very different between mice but, in all cases, high contrast could be observed. Furthermore, 6-[<superscript>18</superscript>F]F- L-DOPA can detect tumours with sizes (1.8 mm<superscript>3</superscript>) that are near the resolution limit of PET, whereas they were undetectable by autopsy at the macroscopic level. 6-[<superscript>18</superscript>F]F- L-DOPA PET imaging can monitor the progression of MTCs in a genetically engineered mouse model. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 37
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 45686425
- Full Text :
- https://doi.org/10.1007/s00259-009-1208-8