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Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood.
- Source :
- European Journal of Pediatrics; 2001, Vol. 160 Issue 3, p168-172, 5p
- Publication Year :
- 2001
-
Abstract
- Colorectal carcinoma rarely affects children and has a dismal prognosis with 5-year survival rates as low as 2.5%-7% despite apparently radical surgery. Here we report the case of an adenocarcinoma of the sigmoid colon in a 15-year-old girl preceded by uncertain abdominal complaints of 5 years' duration. Pathological work-up revealed a tumour with lymph node metastases (pT3NI). Immunohistochemical evidence of p53 overexpression by the tumour cells raised the suspicion of an underlying Li-Fraumeni syndrome. In addition, there were aphthoid ulceration, fissuration of the non-tumorous mucosa, along with a mixed transmural infiltrate composed of macrophages, eosinophils, and non-typical giant cells, which were compatible with simultaneous Crohn's disease. Anamnestic data concerning the occurrence of idiopathic inflammatory bowel disease or colorectal carcinoma in the patient's relatives were non-contributory. The present results suggest a possible relationship between Crohn's disease and colon cancer due to the defective p53 gene product. [ABSTRACT FROM AUTHOR]
- Subjects :
- COLON cancer
ADENOCARCINOMA
CROHN'S disease
P53 antioncogene
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 160
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 4681415
- Full Text :
- https://doi.org/10.1007/s004310000699