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Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups – a UKALLXII study.
- Source :
- British Journal of Haematology; Feb2010, Vol. 148 Issue 3, p394-401, 8p, 1 Chart, 4 Graphs
- Publication Year :
- 2010
-
Abstract
- Cytogenetic and molecular investigations of Acute Lymphoblastic Leukaemia (ALL) have identified the existence of distinct clinical subgroups. Molecular monitoring of clonal Immunoglobulin and T cell receptor (IG/TR) gene rearrangements has become an important tool in stratification of therapy of ALL. In order to determine whether certain features of the patient-specific rearrangements could hold further prognostic clues or provide information on the cell of origin of ALL, a comprehensive analysis of structural and biological features (V gene usage, coding frame and mutational status and complementarity-determining region -III length) of 473 IG/TR rearrangements identified in 229 adults with ALL was carried out. Distinct variable-gene usage profiles were identified between ALL subgroups, particularly for patients positive for BCR-ABL1 compared to MLL-AFF1 positive leukaemias; suggesting that the former is derived from a more mature B progenitor. Interestingly, occurrence of TRGV1- TRGV8 was prognostic for better event-free survival (31% at 4 years with vs. 0% at 4 years without, P = 0·05). The heterogeneity in clinical outcome is suggested by the basic molecular processes of antigen receptor gene rearrangements as shown in this work. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOBLASTIC leukemia
ANTIGENS
CYTOGENETICS
T cell receptors
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 148
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 47445003
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2009.07966.x