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High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats.
- Source :
- Xenobiotica; Feb2010, Vol. 40 Issue 2, p83-92, 10p, 1 Chart, 3 Graphs
- Publication Year :
- 2010
-
Abstract
- 1. 4-n-Nonylphenol and bisphenol A are endocrine disrupting chemicals that are mainly detoxified through glucuronidation. A factor that may modulate their glucuronidation rates is co-exposure to pharmaceuticals. 2. This study aimed to identify and characterize the potential metabolic interactions between 14 drugs and these two endocrine disruptors. 3. Nonylphenol and bisphenol A were co-incubated in freshly isolated rat hepatocytes with, drugs at a high concentration. Statistically significant metabolic inhibition of bisphenol A and nonylphenol biotransformation was observed with nine drugs (>50% inhibition by naproxen, salicylic acid, carbamazepine and mefenamic acid). Inhibition assays of UGT activity in rat liver microsomes revealed: 1) competitive inhibition by naproxen (K<subscript>iapp</subscript> = 848.3 μM) and carbamazepine (K<subscript>iapp</subscript> = 1023.1 μM), 2) no inhibition by salicylic acid suggesting another mechanism of inhibition. 4. Detoxification of nonylphenol and bisphenol A was shown to be impaired by excessive concentrations of many drugs and health risk assessment should therefore address this issue. [ABSTRACT FROM AUTHOR]
- Subjects :
- NONYLPHENOL
BISPHENOL A
DRUGS
LIVER cells
SALICYLIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 00498254
- Volume :
- 40
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Xenobiotica
- Publication Type :
- Academic Journal
- Accession number :
- 47585910
- Full Text :
- https://doi.org/10.3109/00498250903383334