Committed Osteoclast Precursors Colonize the Bone and Improve the Phenotype of a Mouse Model of Autosomal Recessive Osteopetrosis.

The article presents a study which determines whether a support osteoclast precursor therapy may contribute to improve the osteopetrotic phenotype. The researchers have established a procedure to get the best yield of osteoclast precursors from human peripheral blood or mouse bone marrow mononuclear cells. They found that compared with sham-treated mice, animals presented with longer survival, improved weight and longitudinal growth, increased tibial length, tooth eruption, decreased bone volume, reduced bone marrow fibrosis and improved hematopoiesis.