FcεRIα gene ( FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.

Two promoter polymorphisms of the high-affinity IgE receptor α-subunit (FcεRIα) gene ( FCER1A), −66T>C (rs2251746) and −315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the −315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of −315CT/TT genotype or the −315T allele was significantly higher in those with highly elevated total serum IgE concentrations. [ABSTRACT FROM AUTHOR]