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Model-Based Prediction of Defective DNA Mismatch Repair Using Clinicopathological Variables in Sporadic Colon Cancer Patients.
- Source :
- Cancer (0008543X); 4/1/2010, Vol. 116 Issue 7, p1691-1698, 8p
- Publication Year :
- 2010
-
Abstract
- The article presents a study which aims to develop defective DNA mismatch repair (MMR) prediction model in patients with sporadic colon cancer. Clinical and pathological data from 982 patients with resected tumor, nodes, metastasis (TNM) stage II and III colonic adenocarcinomas were analyzed for microsatellite instability and/or MMR protein expression. Results show that the most important predictors of MMR status were tumor site and histological grade which are helpful in clinical decisions.
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 116
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 48915974