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Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women.
- Source :
- Acta Pharmacologica Sinica; Apr2010, Vol. 31 Issue 4, p455-460, 6p, 1 Diagram, 4 Charts
- Publication Year :
- 2010
-
Abstract
- AbstractAim:To investigate whether estrogen receptor α (ER-α) PvuII and osteocalcin (also known as bone Gla protein, or BGP) HindIII genetic polymorphisms and their potential interactions are associated with body mass index (BMI) variation.Methods:Data on BMI and ER-α PvuII and BGP HindIII genotypes were obtained from 328 healthy premenopausal Chinese women in east China. The study subjects were unrelated, at least 21 years old (mean age of 33.2±5.9 years), and had an average BMI of 21.58±2.59. All subjects were genotyped at the ER-α PvuII and BGP HindIII loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).Results:The BGP HindIII genotypes were significantly associated with BMI (P=0.003). Carriers of the HH and Hh genotypes had approximately 2.73% and 1.27% higher BMI than those of the hh genotype, respectively. In contrast, the ER-α PvuII polymorphism was not significantly associated with BMI (P=0.454). In addition, there was no evidence of potential interactions between the ER-α and BGP genes in our subjects (P≥0.013).Conclusion:The HindIII polymorphism of the BGP gene, but not the PvuII polymorphism of the ER-α gene or their potential interaction, was associated with BMI in premenopausal Chinese women. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETIC polymorphisms
PERIMENOPAUSE
PHYSIOLOGY of women
BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 16714083
- Volume :
- 31
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Acta Pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 48950973
- Full Text :
- https://doi.org/10.1038/aps.2010.1