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Determining the breast-feeding interruption schedule after administration of 123I-iodide.
- Source :
- Annals of Nuclear Medicine; Oct1998, Vol. 12 Issue 5, p303-306, 4p
- Publication Year :
- 1998
-
Abstract
- Radioactivity after administration of 123I-sodium iodide was measured in breast milk samples obtained from a patient with postpartum thyroiditis. The breast milk was collected over 93 h during the infant's regular feeding times. The radioactivity in the breast milk was calculated with a 123I capsule of the same lot number as the standard source. 123I was excreted exponentially with an effective half-life of 5.5 h; 2.5% of the total radioactivity administered was excreted in the breast milk over the 93 h, 95% of which was excreted within the first 24 h, and 98.2% within 36 h. The first milk sample collected at 7 h after administration of the radiopharmaceutical contained 48.5% of the total radioactivity excreted. We estimated the potential absorption of radioactivity to an infant's thyroid in uninterrupted breast-feeding to be 30.3 mGy. With a 24-hour interruption, the absorbed radioactivity would be 1.25 mGy; with a 36-hour interruption, it would be 0.24 mGy. According to our calculations, breast feeding should be curtailed for 36 h to reduce the infant's exposure to 123I radioactivity. By using a correction factor based on maximum radioactivity from another 123I capsule of the same lot, we were able to ascertain the appropriate protocol for our patient and establish a measurement method that can be applied in similar clinical situations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09147187
- Volume :
- 12
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Annals of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 49559381
- Full Text :
- https://doi.org/10.1007/BF03164918