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Psyllium improves fecal consistency and prevents enhanced secretory responses in jejunal tissues of piglets infected with ETEC.
- Source :
- Digestive Diseases & Sciences; Nov1998, Vol. 43 Issue 11, p2536-2541, 6p
- Publication Year :
- 1998
-
Abstract
- Infection with enterotoxigenic E. coli (ETEC) induces secretory diarrhea by stimulating net secretion of fluid and electrolytes. We tested the hypothesis that ETEC potentiates jejunal ion secretion induced by other agonists and also examined whether the soluble fiber psyllium ameliorates effects of ETEC-induced pathophysiology. Noninfected or ETEC-infected piglets were given oral electrolyte solution twice daily or electrolyte solution supplemented with psyllium for 48 hr. Jejunal tissues were mounted in flux chambers and basal and stimulated ion transport responses, as reflected by short-circuit current (I(SC)) were measured. The severity of ETEC-induced diarrhea was reduced by psyllium. I(SC) responses to carbachol and 5-hydroxytryptamine were greater in tissues from infected piglets compared with noninfected controls or infected piglets given psyllium. These results suggest that psyllium ameliorates ETEC-induced diarrhea and prevents the enhanced secretory responses to calcium-mediated agonists that occur in ETEC-infected piglet jejunum. [ABSTRACT FROM AUTHOR]
- Subjects :
- PSYLLIUM (Plants)
ANALYSIS of variance
ANIMAL experimentation
ANIMAL populations
BIOLOGICAL transport
COMPARATIVE studies
DIARRHEA
DRUG design
CLINICAL drug trials
ESCHERICHIA coli
ESCHERICHIA coli diseases
FECES
JEJUNUM
LAXATIVES
RESEARCH methodology
MEDICAL cooperation
RESEARCH
SWINE
TOXINS
EVALUATION research
NUTRITIONAL status
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 01632116
- Volume :
- 43
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Digestive Diseases & Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 49833844
- Full Text :
- https://doi.org/10.1023/A:1026611005440