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The synthesis, discovery, and development of a highly promising class of microtubule....

Authors :
Ting-Chao Chou
O'Connor, Owen A.
Tong, William P.
Yongbiao Guan
Zui-Gou Zhang
Stachel, Shawn J.
Chulbom Lee
Danishefsky, Samuel J.
Source :
Proceedings of the National Academy of Sciences of the United States of America; 7/3/2001, Vol. 98 Issue 14, p8113, 6p, 1 Diagram, 8 Graphs
Publication Year :
2001

Abstract

Examines the curative effect of desoxyepothilones B (dEpoB) and F (dEpoF) against human tumor xenografts in mice. Synthesis of microtubule stabilizing agents; Pharmacologic properties of dEopB; Production of nonmultiple drug-resistant human lung carcinoma A549 cells.

Subjects

Subjects :
STABILIZING agents
CANCER

Details

Language :
English
ISSN :
00278424
Volume :
98
Issue :
14
Database :
Complementary Index
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Publication Type :
Academic Journal
Accession number :
4993353
Full Text :
https://doi.org/10.1073/pnas.131153098