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Hepatocyte nuclear factor-1 a gene and non-insulin-dependent diabetes mellitus in the Japanese population.
- Source :
- Acta Diabetologica; Oct1998, Vol. 35 Issue 3, p150-153, 4p
- Publication Year :
- 1998
-
Abstract
- Recently, hepatocyte nuclear factor-1 α (HNF-1 α, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non-insulin-dependent diabetes mellitus (type 2) in Japanese subjects by investigating allelic association with type 2 diabetes use of three markers. We also studied the frequency of the G191D mutation, the only mutation of TCF1 reported so far in late-onset type 2 diabetes. A total of 356 subjects were studied. There were no significant differences in allele frequency of the three markers between patients with type 2 diabetes and control subjects. A G191D mutation was not found in the subjects studied, giving a frequency of less than 0.4% in common type 2 diabetes. The lack of association of type 2 diabetes with three markers in and near TCF1 suggests that mutations in TCF1 derived from a limited number of founders are not a major cause of common type 2 diabetes even in the genetically homogeneous Japanese population. The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09405429
- Volume :
- 35
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Acta Diabetologica
- Publication Type :
- Academic Journal
- Accession number :
- 49944920
- Full Text :
- https://doi.org/10.1007/s005920050120