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Universal Markers of Thyroid Malignancies: Galectin-3, HBME-1, and Cytokeratin-19.
- Source :
- Endocrine Pathology; Jun2010, Vol. 21 Issue 2, p80-89, 10p
- Publication Year :
- 2010
-
Abstract
- Difficulties in diagnosis of thyroid lesions, even with histologic analysis, are well known. This study has been carried on to evaluate the role of immunohistochemical markers including galectin-3, Hector Battifora mesothelial cell-1 (HBME-1), and cytokeratin-19 in the diagnosis and differential diagnosis of benign and malignant thyroid lesions. The expressions of galectin-3, HBME-1, and cytokeratin-19 were tested in formalin-fixed, paraffin-embedded tissues from 458 surgically resected thyroid lesions including non-neoplastic and neoplastic lesions. Immunostaining with standard avidin–biotin complex technique was performed by using monoclonal antibodies. In malignant neoplastic thyroid lesions, galectin-3, HBME-1, and cytokeratin-19 were diffusely expressed in general. Diffuse expression rates of these three markers were 72.3% (47/65), 70.7% (46/65), and 76.9% (50/65), respectively. The use of galectin-3, HBME-1, and cytokeratin-19 may provide significant contributions in the differential diagnosis of malignant thyroid tumors. Although focal galectin-3, HBME-1, and cytokeratin-19 expression may be encountered in benign lesions, diffuse positive reactions for these three markers are characteristic of malignant lesions. It has concluded that cytokeratin-19 alone and its combinations with other markers were more sensitive in accurate diagnosis of papillary carcinoma than the other combinations; meanwhile, there were similar results for follicular carcinomas with HBME-1 alone and its combinations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10463976
- Volume :
- 21
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Endocrine Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 50034605
- Full Text :
- https://doi.org/10.1007/s12022-010-9114-y