Back to Search
Start Over
Optimal use of the 131-I-metaiodobenzylguanidine and cisplatin combination in advanced neuroblastoma.
- Source :
- Journal of Neuro-Oncology; Jan1997, Vol. 31 Issue 1/2, p153-158, 6p
- Publication Year :
- 1997
-
Abstract
- Neuroblastoma (NB), a childhood radiosensitive tumor, is very aggressive and malignant; in its disseminated form, despite very intensive chemotherapy, prognosis continues to be dismal. Owing to its capacity to concentrate in NB lesions, large doses of 131-I-MIBG, have given very encouraging therapeutic results in patients resistant to conventional therapy as well as at diagnosis.We recently reported the first attempt in combination therapy (CO-TH) using 131-I-MIBG and cisplatin. This new form of CO-TH appears very effective in obtaining a rapid and excellent response in relapsed patients.In this report, we describe the results of further experience with CO-TH in disseminated NB. We have attempted to verify to what extent interaction between the effects of the two agents may produce therapeutic benefit, and we have sought the optimization of CO-TH use.Three stage IV NB patients were treated with CO-TH. The following treatment schedule, was planned: day 1, cisplatin 50 mg/m<superscript>2</superscript> i.v. over 6 h; day 2, 131-I-MIBG 100—130 mCi at high specific activity (- 1.1 Gbq/mg) i.v. over 6 h followed, a week later, by the same treatment combination.The therapeutic results were encouraging. However, hematological toxicity continued to represent a major limiting factor. In view of the overall effectiveness of CO-TH, at the price of lasting hematological toxicity, it may be indicated as a consolidationregimen some time before conditioning chemotherapy for autologous bone marrow transplantation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0167594X
- Volume :
- 31
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Journal of Neuro-Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 50046937
- Full Text :
- https://doi.org/10.1023/A:1005770405844