Back to Search
Start Over
B-cell activation in the mesenteric lymph nodes of resistant BALB/c mice infected with the murine nematode parasite Trichuris muris.
- Source :
- Parasitology Research; Feb1999, Vol. 85 Issue 3, p194-199, 6p
- Publication Year :
- 1999
-
Abstract
- Immune responses in resistant BALB/c mice infected with the murine nematode parasite Trichuris muris were examined. Following the establishment of infection, worm burdens of T. muris were expelled by BALB/c mice by day 21 postinfection (p.i.). Specific immunoglobulin G<subscript>1</subscript> (IgG<subscript>1</subscript>) antibodies to T. muris excretory/secretory (E/S) antigens were detected in sera from infected mice, though specific IgG<subscript>2a</subscript> antibodies were not observed during infection. Ig-producing cells increased in the mesenteric lymph nodes (MLN) of infected mice on days 7, 14, and 21 p.i., with the greatest increase in numbers of IgG- and IgA-producing cells occurring on day 14. Marked increases in the relative percentages of B220<superscript>+</superscript> and surface Ig<superscript>+</superscript> (sIg<superscript>+</superscript>) cells were observed in the MLN of infected mice on days 14 and 21 p.i. Furthermore, cellular expansion of the MLN in infected mice resulted in an increase in the absolute numbers of B220<superscript>+</superscript> and sIg<superscript>+</superscript> cells. The levels of interleukin 2 (IL-2), IL-4, and interferon-γ (IFN-γ) detected in the supernatants from concanavalin A-stimulated MLN cells of infected mice were higher than those found in normal mice. Consequently, the expulsion of T. muris in resistant BALB/c mice was concomitant with cytokine production and B-cell activation in the MLN of infected mice. These results suggest the involvement of B-cell responses in protective immunity to T. muris infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09320113
- Volume :
- 85
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Parasitology Research
- Publication Type :
- Academic Journal
- Accession number :
- 50148494
- Full Text :
- https://doi.org/10.1007/s004360050534