HIV-1 autoreactive antibodies: are they good or bad for HIV-1 prevention?

The article comments on research study published in the issue related to Human Immunodeficiency Virus (HIV)-1 envelop. It states that the influenza, neutralizing antibodies take more time to develop in the transmitted person. As stated, traits including heavy chain determining regions, high levels of somatic mutations and polyreactivity with a variety of host molecules found in neutralizing antibodies. It also comments that the antibodies are derived from the T cell independent mechanisms.